(185c) Bionanotubes of Escherichia Coli K-12 and Its Application in Facilitated Membrane Transport of Biological Molecules

CNT (carbon nanotube) has been recognized to be effective for drug design in the context of DC (concentration gradient) as driving force, made on the surface of targeted cells, belonging either in pathogenic microbes, or as cancer cells or as antigens of toxic properties. CNT can develop site-specific cancer drug delivery by encapsulating /tagging anti cancerous nano-gram chemicals in the branches dendrimers (1-5 nm) and can bring those to the targeted cells. For example methotrxate, fluorescine, folic acid in case of cancer therapy. CNT will work as carrier of these products in their tube and will attract cancer cells as part of folic acid and destroy by bringing cytotoxic elements to cancerous cells at low concentrations where the side effects would be reduced. BNT (biological nano-tube) as isolated fimbriae =pili of Escherichai coli (E.coli) can work indirectly by stimulating the macrophages through inductions of T and B memory cells. Engineered E.coli was used and was designed by means of plasmid genetic engineering of donor bacterium or Escherichia coli., causing diseases to human and domestic animals. In this paper the author will discuss how such ?Bio-nanotube= fimbriae=pili ? are being made and how this could be utilized as facilitated transport to convert cell membrane for active transport of biological system. Protein, elongated appendages of the surface cell wall of Escherichia coli can play both in active transport for cell lyses or can play as passive role in stimulating lymphokines, cytokines or can attract targeted toxic=pathogenic cells for engulfing, phagocytosis and pinocytosis. This paper will discuss also how this filbriae=pili are working in stimulating the macrophages and how charges of these fimbriae=pili are being involved to bind cells, and flocculate the substrates.