(64e) Generation and Reactions of Ortho-Bromophenyllithium without Benzyne Formation Using Microflow System
AIChE Spring Meeting and Global Congress on Process Safety
2008
2008 Spring Meeting & 4th Global Congress on Process Safety
IMRET-10: 10th International Conference on Microreaction Technology
Fine Chemicals and Pharmaceuticals Synthesis and Production – Part 2
Monday, April 7, 2008 - 3:40pm to 4:05pm
Lithiation of 1,2-dibromobenzene to generate ortho-bromophenyllithium is usually carried out at low temperatures, such as -110 oC in order to avoid benzyne formation. The use of a microflow system enables the generation of ortho-bromophenyllithium and its reactions with electrophiles at higher temperatures by virtue of efficient heat transfer and precise residence time control.
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