(85c) Safely Scale-up Processes and Accommodate Recipe Changes

Thermal hazards screenings can be quickly and cost-effectively performed to obtain the require data for safe scale-up of chemical processes and to accommodate changes to process recipes. Prior to scale-up, it is vital to identify safe temperature and pressure operating ranges, quanify the heat generated from a reaction and the number of moles of gas generated. It is also prudent to determine the heat and gas generation rates in order to safely accommodate the reaction in the given process equipment. These rate data can also be used to verify the adequacy of the existing pressure relief system design. When a process recipe or batch size is changed, data are necessary to quanitify the effect of the change on the above parameters. HAZOP reviews identify credible upset scenarios, and the data are required to address these issues. All of these data are readily available by performing calorimetry experiments with the Advanced Reactive System Screening Tool and examples of these applications are provided.