(110c) Pilot Plant Retooling for a More Reliable Process Scale-up
AIChE Spring Meeting and Global Congress on Process Safety
2011
2011 Spring Meeting & 7th Global Congress on Process Safety
Process Development Division
Best Practices and Case Studies In Process Development
Wednesday, March 16, 2011 - 2:55pm to 3:20pm
Piloting a new process at a smaller scale before rolling it out to the larger manufacturing facility presents numerous scale-down as well as scale-up challenges. This paper will focus on several case studies to illustrate best practices we learned through experience for a successful scale-up. The paper will cover the following case studies –
- Improving liquid-liquid separation through the use of a coalescer centrifuge and scale-up of the same
- Lowering the contamination of polymer with residual monomer through modifications in reactor design.
- Enhancing pilot plant capability through the use of a concentrator