(210c) Approaches to Multiblock Modeling and Dimension Reduction for Combining Disparate Data Types

Continuous manufacturing, which is being strongly promoted by the FDA, is an innovative approach to pharmaceutical processing that utilizes information from multiple sensors throughout the entire process. Due to the numerous factors that need to be monitored and controlled at the same time, a multi-step approach is necessary for optimizing individual unit operations as well as the overall process. In this presentation we will show some approaches to combining process and spectroscopic data, which can be applied to process monitoring for continuous manufacturing as well as for batch processes.