(95e) Process Safety and Scale-up Strategy for Coating Polymers

Process safety is key part of scale-up from lab to pilot to production. A comprehensive scale-up strategy that encompasses each step will be presented. Calorimetry and its importance at validating reaction kinetics, vent sizing, and exothermic reaction modeling will be discussed. Value of this key information in understanding the thermal safety of chemical processes, risk assessment, and process design as part of the scale-up protocol will be outlined. Design, development, and scale-up of phenolic resins will be given as a case study. The approach will outline the significance of modeling, design of experiments, latitude studies, pilot batches, to make data driven decisions as part of the commercialization process.