Glucose-Derived Cationic Block Poly(?-peptides) for Potentiating Antibiotics Against Gram-Negative Bacteria

Carbapenem-resistant gram-negative bacteria are at the top of The World Health Organization (WHO) list of pathogens for which antibiotics are critically needed. In addition of their propensity to acquire antimicrobial resistance genes through horizontal gene transfer, the presence of an outer membrane and multiple efflux pump systems confers a high degree of intrinsic drug resistant in gram-negative pathogens. Many antibiotics are either unable to penetrate the outer membrane layer, or are excluded from the cytosol by efflux mechanisms.