Session Chair:
- Robert Gallogly, BASF
Schedule:
| PRESENTATION | SPEAKER |
| Scale-Up of Agitated Drying: Effect of Shear Stress and Hydrostatic Pressure on API Powder Properties | Brenda Remy, Bristol-Myers Squibb |
| Open Questions in Modeling Collision, Coalescence and Breakage Processes | R. Bertrum Diemer, DuPont Company |
| The Importance of Fluid-Particle Interactions for Fluidized Systems Modeling | Peter Blaser, CPFD Software |
Scale-Up of Agitated Drying: Effect of Shear Stress and Hydrostatic Pressure on API Powder Properties
Brenda Remy, Bristol-Myers Squibb
Roughly 80% of commercial pharmaceutical products utilize oral solid dosage formulations. In these formulations, the Active Pharmaceutical Ingredient (API) particle size can influence stability, bioavailability, dissolution rate and content uniformity of the drug product. For this reason, the pharmaceutical industry devotes significant effort to developing fundamental understanding of the processes that govern API particle size. Much of that effort has historically focused on crystallization development, whereas fundamental understanding of particle agglomeration and attrition in the subsequent agitated drying step is less well established. One reason is that traditional laboratory drying equipment has not successfully reproduced the degree of agglomeration or attrition observed at scale. This work characterizes the propensity for particle attrition to occur at different stages of the drying process by employing a laboratory agitated dryer that has been modified to measure impeller torque and reproduce the range of hydrostatic pressures observed during scale-up. A workflow for assessing risk of API attrition at manufacturing scale is described.
Open Questions in Modeling Collision, Coalescence and Breakage Processes
R. Bertrum Diemer, DuPont Company
Population balance models are potentially useful for design and scaleup of particle processing operations, but much is missing that would enable broader application of these approaches to real problems. This paper will describe some of the gaps that need to be closed in order to better connect experiments, models and equipment design.
The Importance of Fluid-Particle Interactions for Fluidized Systems Modeling
Peter Blaser, CPFD Software
This presentation discusses the importance of capturing fluid-particle interactions in computational models of fluidized systems. While direct particle to particle interactions are certainly important and computational modeling in general would benefit from an improved understanding of these interactions, a primary interaction mechanism influencing fluidized systems is the interaction between the particles and fluid. This presentation discusses the importance of fluid-particle coupling via aerodynamic/hydrodynamic drag, how particle-fluid interactions impact particle to particle interactions, validation of modeling for fluidized industrial systems, the effect of particle size distribution including fines, limitations of existing models, and how current research trends can enable expanded industrial application of modeling technology impacting efficient and rapid commercialization and scale-up of new and improved particle technologies.