Technical Program for ME15 | AIChE

Technical Program for ME15

All times listed in SGT ...

All times listed in SGT

View Abstracts Here View Poster Numbers Here

June 11, 2023 (Sun)

13:30-17:00 Registration and Badge Pick-Up

15:15-15:30

Opening Remarks

15:30-16:00

Plenary Talk 1

Session Chair: Christine Santos, Manus Bio

Systems Metabolic Engineering of Bacteria

Sang Yup Lee, KAIST

16:00-16:30

Lightning Session 1

Session Chair: Hal Alper, The University of Texas at Austin

16:00 Crispri Repression Screens Reveal Tradeoffs between Growth Rate and Robustness in Cyanobacteria in Various Trophic Conditions

Rui Miao, Royal Institute of Technology
16:05 Producing Psychedelic Medicines – the Next Generation of Mental Health Treatment

J. Andrew Jones, Miami University
16:10 Metabolic Pathway Assembly Using Docking Domains from Type I Cis-at Polyketide Synthases

Tian Ma, Shenzhen Institute of Advanced Technology
16:15 Metabolomics-Guided Discovery of Metabolic Design Principles and Engineering Strategies

Junyoung Park, University of California, Los Angeles
16:20 Upgrading Pseudomonas Putida By Systems Metabolic Engineering for Biotechnological Processing of Lignocellulosic Sugars

Pavel Dvorak, Masaryk University

16:25-17:00

Break

17:00-18:15

Session 1: Metabolic Engineering for Next-Generation Agrifood

Session Chairs: Anastasia Krivoruchko, Melt&Marble & Claudia Vickers, Queensland University of Technology

17:05

Metabolically engineered microbes for a sustainable agri-food industry: From the valorization of waste streams to the synthesis of agrochemicals, food preservatives, and essential nutrients

Christoph Wittmann, Saarland University

17:20 Sustainable Production of Ingredients for Vast Range of Applications with Example of Advances in Microbial Production of Natural Sweeteners

Elena Brevnova, Conagen
17:30 Precision Fermentation for Producing Food Ingredients and Fermented Foods

Yong Su Jin, University of Illinois at Urbana-Champaign
17:40 Green Vitamin A: A World’s First Bio-Based Process

Liang Wu, DSM-Firmenich
17:50 Panel Discussion

18:15-18:35

Rapid Fire Session 1: 1-20

18:30-21:00

Poster Session 1A & Opening Reception

June 12, 2023 (Mon)

7:30 - 8:30 Registration and Badge Pick-Up

7:30-8:30

Networking & Coffee

8:30-9:00

Plenary Talk 2

Session Chair: Guhan Jayaraman, Indian Institute of Technology Madras



Substrate-driven control of biosynthetic pathways towards mixed-feed utilization

Kristala Prather, Massachusetts Institute of Technology

9:00-10:30

Session 2: Next-Generation Analytics for Metabolic Engineering

Session Chairs: Tomohisa Hasunuma, Kobe University & Byung Kwan Cho, KAIST

9:05

Metabolic Engineering using Microdroplets

Hal Alper, The University of Texas at Austin

9:20 Comamonas Testosteroni As a New Chassis for Lignin and Plastics Valorization

Ludmilla Aristilde, Northwestern University
9:30 Label-Free and High-Throughput Sorting of Metabolic Phenome for Microbial and Mammalian Cell Factories By Flow-Mode Raman-Activated Cell Sorting (FlowRACS)

Jian Xu, Qingdao Institute of BioEnergy and Bioprocess Technology, Chinese Academy of Sciences
9:40 Pinpointing Metabolite Cross Feeding Interactions in Microbial Communities Using a Novel 13C Metabolic Flux Analysis Approach

Maciek Antoniewicz, University of Michigan
9:50 Nonlinear Dynamic Models of Metabolism Derived By AI for Metabolic Engineering Applications

Ljubisa Miskovic, Swiss Federal Institute of Technology (EPFL)
10:00 Panel Discussion

10:30-11:00

Break

11:00-12:15

Session 3: Big Data and Artificial Intelligence for Metabolic Engineering

Session Chairs: Dong Yup Lee, Sungkyunkwan University & Pablo Carbonell, Universitat Politècnica de València

11:05 Artificial Intelligence (AI)-Enhanced Structure Dynamics-Guided Biocatalyst Design

Susie Dai, Texas A&M University
11:15

Characterization and Engineering of Microbial Metabolism By Using Bio Big Data and Machine Learning

Hyun Uk Kim, Korea Advanced Institute of Science and Technology (KAIST)

11:25 Deep Learning Driven Biosynthetic Pathways Navigation for Natural Products with Bionavi

Ruibo Wu, Sun Yat-sen University
11:35 Bridging Machine Intelligence and Synthetic Biology for Understanding and Engineering of Biological Systems

Aleksej Zelezniak, Chalmers University of Technology
11:45 Panel Discussion

12:15-13:15

Lunch - Sponsored Workshop Presented by Inscripta: Overcoming the Risks in Synthetic Biology Product Development through Genome Scale Metabolic Engineering, Richard Fox

Lunch Location - Peony Ballroom, Workshop Location: Orchid Ballroom

13:15-14:30 Poster Session 1B

14:30-15:45

Session 4: Metabolic Engineering for Multi-Cellular Systems

Session Chairs: Zengyi Shao, Iowa State University & Rodrigo Ledesma-Amaro, Imperial College London

14:35

Animal Free Glycosaminoglycans: biosynthesis of chondroitin sulfate and heparin using metabolic engineering approaches.

Mattheos Koffas, Rensselaer Polytechnic Institute

14:50 Bacterial Metabolites Essential for Post-Embryonic Development of C. Elegans

Qing Sun, Texas A&M University
15:00 Challenges & Opportunities of Mixotrophic Syntrophic Cocultures Enabling CO2 Fixation to Achieve Transformative Product Yields

Eleftherios Terry Papoutsakis, University of Delaware
15:10 Optimization of Strigolactone-Producing Bacteria-Yeast Consortium

Yanran Li, University of California, Riverside
15:20 Panel Discussion

15:45-16:15

Lightning Session 2

Session Chair: Hal Alper, The University of Texas at Austin

15:45 Engineering Synthetic Carbon Fixation in Escherichia coli

Sebastian Wenk, Max Planck Institute of Molecular Plant Physiology
15:50 Eubacterium Limosum as a Chassis for High-Efficiency Bioproduction from C1 Substrates

Benjamin Woolston, Northeastern University
15:55 Computer-Aided Design and Implementation of Efficient Biosynthetic Pathways to Produce High Added-Value Products Derived from Tyrosine in Escherichia coli

Sofia Ferreira, ITQB-NOVA
16:00 The Biophotovoltaics for Biohydrogen Production Using Sunlight and Water

Bin Lai, Helmholtz Centre for Environmental Research - UFZ
16:05 Establishing Pichia Pastoris As a Chassis for the Production of Plant Natural Products

Jiazhang Lian, Zhejiang University
16:10

Transcription-Associated Molecular Reaction Cascades for Diagnostics and Prototyping

Jeong Wook Lee, POSTECH 

16:15-16:45

Break

16:45-18:05

Session 5: Metabolic Engineering for Next-Generation Medicine

Session Chairs: In Young Hwang, Singapore Institute of Technology & Chun Loong Ho, Shenzhen Institute of Advanced Technology

16:50 SynBio-Driven Biosystems Design for the Innovative Bio-industrialization

Zixin Deng, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Wuhan University
17:05 Metabolic Engineering for Production of the Drug Candidates Scyllo-Inositol and D-Chiro-Inositol

Michael Bott, Institute of Bio- and Geosciences
17:15 Engineering Strategies for Higher Production of Aromatic Amino Acid Derivatives in Saccharomyces Cerevisiae

Yunzi Luo, Tianjin University
17:25 An Integrated Technology Platform for Microbial Biosynthesis

Michal Pyc, Willow Biosciences Inc.
17:35 Panel Discussion

18:05-18:25

Rapid Fire Session 2: 21-40

18:25-21:00

Poster Session 2A & Reception

June 13, 2023 (Tue)

7:30 - 8:30 Registration and Badge Pick-Up

7:30-8:30

Networking & Coffee

8:30-9:10

Greg Stephanopolous Award Lecture: Metabolic Engineering in Future Society

James Liao, 
Academia Sinica

9:10-10:30

Session 6: Future of Metabolic Engineering

Session Chairs: Kristala Jones Prather, MIT & Sang Yup Lee, KAIST

9:15 New frontiers of Metabolic Engineering

Greg Stephanopoulos, Massachusetts Institute of Technology
9:25

Innovation Trends in Metabolic Engineering

Jens Nielsen, BioInnovation Institute

9:35 Engineering yeast to synthesize medicinal compounds via an integrated systems approach

Christina Smolke, Stanford University
9:45 New Challenges in Metabolic Engineering and Biofoundry

Akihiko Kondo, Kobe University
9:55 Panel Discussion

10:30-11:00

Break

11:00-12:20

Session 7: New-to-Nature Chemistry for Metabolic Engineering

Session Chairs: Pablo Ivan Nikel, Technical University of Denmark & Julius Fredens, National University of Singapore

11:05 Engineering microbial metabolism for new-to-nature chemistry and products

Jay Keasling, University of California, Berkeley
11:20 New Keys to Unlock the Treasure Trove of Microbial Natural Products

Nigel Mouncey, DOE Joint Genome Institute
11:30 Engineering Production of New-to-Nature Terpenoids in Saccharomyces Cerevisiae

Codruta Ignea, McGill University
11:40 Posttranslational Formation of Cyclophanes in Bacteria

Brandon Morinaka, National University of Singapore
11:50 Panel Discussion

12:15-13:15

Lunch Workshop Sponsored by Conagen: Synthetic Biology for the Production of Sustainable, Performance Materials and their Applications in Consumer Goods, Casey Lippmeier

Lunch Location - Peony Ballroom, Workshop Location: Orchid Ballroom

13:15-14:30 Poster Session 2B

June 14, 2023 (Wed)
7:30 - 8:30 Registration and Badge Pick-Up

7:30-8:30

Networking & Coffee

8:30-9:00

Plenary Talk 3

Session Chair: Pimchai Chaiyen, VISTECH



The Carbon Revolution: Scaling circularity to replace fossil oil 

Michael Koepke, LanzaTech

 

9:00-10:30

Session 8: Next-Generation Feedstock for Metabolic Engineering

Session Chairs: Mark Blenner, University of Delaware & Ben Woolston, Northeastern University

9:05

Upgrading CO2 to Value-Added Chemicals Via Cell-Free Systems

Pamela Peralta-Yahya, Georgia Institute of Technology

9:15

Teaching Old Dogs New Tricks — Elucidating Core Design Principles to Engineer Nonconventional Yeasts and Consortia As Microbial Factories

Zengyi Shao, Iowa State University

9:25

Macroalgae Biorefinery: New Opportunity of Metabolic Engineering

Gyoo Yeol Jung, POSTECH

9:35 Engineering Methyltrophic Yeasts As Next-Generation Chassis for Biomanufacturing Chemicals from Methanol

Yongjin Zhou, Dalian Institute of Chemical Physics
9:45

New Metabolic Engineering Strategies for Producing Oleochemicals in Microbes

Brian Pfleger, University of Wisconsin-Madison

9:55 Panel Disussion

10:30-11:00

Break

11:00-12:30

Session 9: Next-Generation Chassis for Metabolic Engineering

Session Chairs: Jens O. Krömer, Helmholtz-Centre for Environmental Research & Jiazhang Lian, Zhejiang University

11:05

CRISPR-Cas toolkits for genome scale functional genomics in non-model microbes 

Carrie Eckert, Oak Ridge National Laboratory

11:20

The Weizmann Process Revisited for Advanced Lignocellulosic Biofuel Production

Philippe Soucaille, Toulouse University

11:30 Gene-Editing and Mining of Novel Gene-Elements in Non-Model Rhodococcus

Huimin Yu, Tsinghua University
11:40 Harnessing Lignocellulolytic Anaerobic Fungi for Metabolic Engineering

Kevin Solomon, University of Delaware
11:50 Computational Biology-Guided Microbial Engineering Empowers Artificial Intelligence-Guided Bioprocess Design to Achieve Record Algal Productivity

Joshua Yuan, Washington University in St. Louis
12:00 Panel Discussion

12:30-14:00

Lunch & Networking

14:00-15:30

Session 10: Synthetic Biology for Metabolic Engineering

Session Chairs: Han Li, University of California, Irvine & Aditya Kunjapur, University of Delaware

14:05 Metabolic engineering of yeasts for the production of betalain-type natural colors

Irina Borodina, Technical University of Denmark
14:20 Towards Universal Synthetic Heterotrophy in Baker’s Yeast. or Why to Stop Fighting Cellular Nature with Engineering Goals

Nikhil Nair, Tufts University
14:30 Efficient Production of Various Disubstituted Mycosporine-like Amino Acids, Natural Sunscreen Materials, in Yeasts

Ji-Sook Hahn, Seoul National University
14:40 Next-Generation Tools for Metabolic Engineering

Rodrigo Ledesma Amaro, Imperial College London
14:50 Retrosynthetic Pathway Design and Enzyme Engineering for Cis-α-Irone Biosynthesis

Xixian Chen, Singapore Institute of Food and Biotechnology Innovation, Agency for Science, Technology and Research
15:00 Panel Discussion

15:30-16:00

Break

16:00-16:20

Lightning Session 3

Session Chair: Hal Alper, The University of Texas at Austin

16:00 Membrane-Free ATP Production from Electricity

Shanshan Luo, Max Planck Institute for Terrestrial Microbiology
16:05 How the Biosynthesis of Non-Standard Amino Acids Can Enable New Forms of Vaccines, Antibiotics, and Biological Containment

Aditya Kunjapur, University of Delaware
16:10

Biosynthesis of Mushroom-Derived Ganoderic Acids By Engineered Yeast

Han Xiao, Shanghai Jiao Tong University

16:15 Complete Biosynthesis of QS-21 in Engineered Yeast

Yuzhong Liu, University of California, Berkeley

16:20-17:45

ME15 Award Ceremony

James E. Bailey Award

Poster Awards




International Metabolic Engineering Award Lecture: Next Generation Industrial Biotechnology based on Synthetic Biology of Halomonas spp.

George Guo-Qiang Chen, 
Tsinghua University

17:45 - 18:30 Transit to Banquet

18:30-22:00

Conference Banquet

Flower Field Hall, Gardens by the Bay

22:00-00:00

Flower Dome Visit

June 15, 2023 (Thu)

7:30-9:00 Registration and Badge Pick-Up

7:30-9:00

Networking & Coffee

9:00-10:30

Session 11: Biofoundries: Automation in Metabolic Engineering

Session Chairs: Eriko Takano, Manchester Institute of Biotechnology & Pengfei Xia, Shandong University

9:05

Recent Advances in Biofoundry Development

Huimin Zhao, University of Illinois Urbana-Champaign

9:20 Enabling Exquisite Control in Cell-Free Biomanufacturing with Orthogonal Redox Cofactors

Han Li, University of California-Irvine
9:30 Design to Learn, Learn to Design: The Dual Challenge of Automated Strain Engineering

Lars Nielsen, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland
9:40 Automating Adaptive Laboratory Evolution to Generate a Full Technology Platform

Adam Feist, University of California, San Diego
9:50 Engineering Oleaginous Yeast for Novel Food Ingredients

Maciej Holowko, Nourish Ingredients
10:00 Panel Discussion

10:30-11:00

Break

11:00-12:30

Session 12: Metabolic Engineering for Biomanufacturing: From Lab to Industry

Session Chairs: Wataru Mizunashi, NEDO & Hal Alper, The University of Texas at Austin

11:05 Microbial Production and Downstream Conversion of Building Block Chemicals for Consumer and Industrial Products in a Fully Vertically Integrated Company

Rebecca Lennen, Lygos, Inc.
11:15 Performing in Spite of Stress: How to Engineer a Robust E. coli Chassis for Large Scale Application

Ralf Takors, Institute of Biochemical Engineering, University of Stuttgart
11:25 Data-Driven Design and Development of Commercial and Scalable Cell Factories

Harish Nagarajan, Genomatica, Inc
11:35 Crossing the Valley of Death to Commercialization:  Manus' Journey by Christine Santos, Manus Bio
11:45 Metabolic Engineering: Made to Scale

Kelly Smith, DMC Biotechnologies
11:55 Panel Discussion

12:30-12:45

Closing Remarks