End-to-end bioprocessing models to assess process robustness and inform control strategies

In this talk we will describe examples of how Siemens customers are building and applying dynamic end-to-end mechanistic models of integrated and continuous biomanufacturing processes (ICB) to determine the impact of expected disturbances, deviations, and uncertainties on product quality. We will show practical examples where these models can generate value by performing tasks which are not possible experimentally due to the prohibitive material requirements and complexity of building end-to-end processes in the lab.