The Fast Track for Chemical Process Development: Brains + Experiments + Models = Success.

Successful process development and scale-up is hard work. How can you get more value from your lab experiments and pilot plant runs? How can you ensure your scale-up will go well?

We outline a development and scale-up strategy that combines mechanistic thinking, experiments and modeling. Scientists and engineers at companies around the world routinely apply this approach to work together more effectively; to improve technology exchange within their organizations and with contract research and manufacturing organizations; to design fewer, better experiments; and to scale-up to kilo lab, pilot plant and full-scale manufacturing successfully. We will present case studies spanning unit operations including chemical reactions, crystallization, solvent exchange and solid-liquid separation to illustrate the strategy and benefits attained.