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This work describes the Quality Assurance (QA) and Quality Control (QC) process for pressure relief studies. Definitions are given for the terminology used for the QA/QC process of pressure relief system studies. A sample workflow of a typical pressure relief system analysis is given. Different sections of the pressure relief analysis are briefly described and sample work instructions are given for each section. A typical set of the documentation required for a pressure relief system study and a typical sequence of the documents therein are described. Work instructions are given for the QA/QC process in the different sections of the studies- setup, overpressure contingency analysis, concerns identification and the final documentation. The final deliverables and a typical approval procedure for the final documentation is also given. The storing and maintaining the pressure relief studies is covered briefly. Lastly, some common pitfalls observed in QA/QC of hundreds of pressure relief systems from commercial refineries and petrochemical plants are described.