(113c) Simulating Bilayer Tablet Compaction: Effect of Compaction Parameters and Material Properties on Tablet Attributes

Bi-layer tablets have received much attention in the last five years as it provides an efficient method to achieve controlled drug delivery with predefined release profiles. However, there are many challenges associated with the manufacture of bi-layer tablets which makes them prone to delamination. In this work finite element method (FEM) computer simulation of bilayer tablet compaction is presented. The influence of layer material properties and compaction parameters viz. the tamp force and main compression force on bi-layer tablet compaction is reported. Generally the results showed, the successful production of a bi-layer tablet is achieved by using a low tamp force and a high main compression force. The mechanical properties of the bi-layer mixtures also play a role in post compaction behavior of the powder compact. The results suggest that by controlling the material properties and compaction process parameters a robust space may be found for the production of bilayer tablets.