(95l) Effect of Particle Size Distribution and Wettability on Penetration Behavior, Granule Formation and Granule Properties in Single Drop Granulation

In wet granulation, single drop granulation (where one drop forms one granule) can simplify the complexity and reveal the fundamentals of the interaction between the liquid and the powder bed. Combining drop penetration time, granule formation mechanisms and the characterization of granule properties is a novel study to achieve a comprehensive map of the single drop granulation process, which is relevant in particulate applications like pharmaceuticals, detergents, agricultural chemicals and catalysts.

In this work, single drop impact of liquid on a static powder bed was studied to investigate the granule formation mechanism, droplet penetration time, and the characterization of granule properties (morphology, internal structure and content uniformity). Water was used as the liquid binder and two pharmaceutical powders, microcrystalline cellulose (MCC) (mean particle size ~54.8 μm, contact angle with water ~36°) and acetaminophen (APAP) (mean particle size ~9.74 μm, contact angle with water ~89°), were mixed to make heterogeneous powder beds with varying compositions. The complete drop impact and penetration was recorded with a high-speed camera. The granule morphology, its internal structure and content uniformity were characterized by the prism method with image analysis, micro-CT and UV-vis spectrometry, respectively. Besides the current MCC and APAP system, MCC and APAP with other particle sizes and relative contact angles will also be studied. It is believed that the mean particle size of the powder bed is predominant in influencing the granule formation mechanism, drop penetration time, and granule properties.