Technical Program
Technical Program for the 6th International Conference on CRISPR Technologies.
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| Start Time | End Time | |
| October 17, 2023 | All Eastern Standard Time | |
| Day 1 | ||
| 8:00 AM | 4:00 PM | Registration |
| 9:00 AM | 9:10 AM | Welcome Remarks by Chairs: Kristin Knouse, MIT, Andrew Anzalone, Prime Medicine, & Benjamin Kleinstiver, Harvard |
| 9:10 AM | 10:00 AM | KEYNOTE: Base editing and prime editing: correcting mutations that cause genetic disease in cells, animals, and patients, David Liu, Broad Institute |
| 10:00 AM | 10:30 AM | Morning Coffee Break Sponsored by Synthego |
| 10:30 AM | 12:25 PM | CRISPR Biology, Tools, and Applications; Session Chairs: Jonathan Strecker & Andrew Anzalone |
| 10:30 AM | 10:55 AM | Invited Speaker: CRISPR-like RNAs regulate expression of cas genes, Sergey Shmakov, NIH |
| 10:55 AM | 11:20 AM | Invited Speaker: Uncovering the functional diversity of rare CRISPR-Cas systems with deep terascale clustering, Soumya Kannan, Broad Institute |
| 11:20 AM | 11:45 AM | Invited Speaker: Precision genome editing with DNA-dependent DNA polymerases and exogenous DNA-containing templates, Erik Sontheimer, University of Massachusetts |
| 11:45 AM | 12:05 PM | Selected Abstract: RNA-Guided Type V CRISPR Nucleases Are Small, Efficient Genome Editing Tools with Diverse Targeting Capabilities, Lisa M. Alexander, Metagenomi |
| 12:05 PM | 12:25 PM | Selected Abstract: Dynamics and Mechanics of R-Loop Formation during DNA Interrogation By Cas12a from Different Species, Kevin Aris, Stanford University |
| 12:25 PM | 1:25 PM | Lunch |
| 1:25 PM | 2:55 PM | Epigenetic and RNA editing Session Chairs: Morgan Maeder & Kristin Knouse |
| 1:25 PM | 1:50 PM | Invited Speaker: Unlocking OPERA Platform to Activate Transcription Factor, Venkat Krishnamurthy, Korro Bio |
| 1:50 PM | 2:15 PM | Invited Speaker: Enhancing Genome and Transcriptome Engineering: New Approaches, New Challenges, Prashant Mali, UC San Diego |
| 2:15 PM | 2:35 PM | Selected Abstract: Development of Cas12a for Multiplexed Genome-Scale Transcriptional Activation Yanjing Liu, The Broad Institute of MIT and Harvard |
| 2:35 PM | 2:55 PM | Selected Abstract: Next-Generation Epigenome Editors As Tools for Basic Discovery and Therapeutic Intervention, Edwin Neumann, MIT, Whitehead Institute for Biomedical Research |
| 2:55 PM | 3:25 PM | Afternoon Coffee Break |
| 3:25 PM | 5:20 PM | High-Throughput Functional Genomics Session Chairs: Kristin Knouse & Manda Arbab |
| 3:25 PM | 3:50 PM | Invited Speaker: CRISPR-based decoding of disease-associated genomic variants, Richard Sherwood, Brigham and Women's Hospital |
| 3:50 PM | 4:15 PM | Invited Speaker: Single-cell high-content screening via genomic perturbation profiling at scale, Paul Blainey, MIT and Broad Institute |
| 4:15 PM | 4:40 PM | Invited Speaker: Karyocreate: A CRISPR-based technology to study chromosome-specific aneuploify by targeting human centromeres, Teresa Davoli, NYU |
| 4:40 PM | 5:00 PM | Selected Abstract: Reprogramming Functional Transcription Factor Binding Sites in Regulatory DNA with Pooled Prime Editing, Michael Montgomery, Stanford University |
| 5:00 PM | 5:20 PM | Selected Abstract: Mapping the Genetic Interaction Network of PARP Inhibitor Response, Jia Ling, Princeton University |
| 5:20 PM | 6:20 PM | Poster Session 1 and Cocktail Reception Sponsored by Collaborative Center for X-linked Dystonia Parkinsonism |
| Start Time | End Time | |
| October 18, 2023 | All Eastern Standard Time | |
| Day 2 | ||
| 8:30 AM | 4:00 PM | Registration |
| 9:00 AM | 9:10 AM | Welcome Remarks by Chair: Andrew Anzalone, Prime Medicine |
| 9:10 AM | 10:00 AM | KEYNOTE: From reading the genome for risk to rewriting it for cardiovascular health, Sekar Kathiresan, Verve Therapeutics |
| 10:00 AM | 10:30 AM | Morning Coffee Break |
| 10:30 AM | 12:25 PM | Progress Towards The Clinic Session Chairs: Morgan Maeder & Manda Arbab |
| 10:30 AM | 10:55 AM | Invited Speaker: Correcting Pathogenic Mutations via Prime Editing, Gerald Schwank, University of Zurich |
| 10:55 AM | 11:20 AM | Invited Speaker: Base editing rescue of spinal muscular atrophy in cells and in mice, Mandana Arbab, Harvard Medical School |
| 11:20 AM | 11:45 AM | Invited Speaker: Modularity of In Vivo CRISPR Therapies, Jonathan Phillips, Intellia Tx |
| 11:45 AM | 12:05 PM | Selected Abstract: Gene Editing without Ex Vivo culture Evades Genotoxicity in Human Hematopoietic Stem Cells, Jing Zeng, Boston Children's Hospital |
| 12:05 PM | 12:25 PM | Selected Abstract: Rapid, Definitive Treatment of Phenylketonuria in Variant-Humanized Mice with Corrective Editing, Dominique Brooks, University of Pennsylvania |
| 12:25 PM | 1:55 PM | Lunch Workshop: Challenges for CNS Delivery Sponsored by Collaborative Center for X-linked Dystonia Parkinsonism; Session Chair: Mandana Arbab & Ben Kleinstiver |
| 12:40 PM | 12:55 PM | Structure-activity relationships guided engineering of AAV capsids with optimized skeletal muscle, cardiac muscle, and CNS tropism, Charlie Albright, Affinia Therapeutics |
| 12:55 PM | 1:10 PM | Invited Speaker: Targeted Gene Regulation in the CNS Using Engineered Zinc Finger Protein Transcription Factors, Andrew Young, Sangamo Therapeutics |
| 1:10 PM | 1:25 PM | Invited Speaker: Teaching old AAVs new tricks: enhancing CNS gene delivery by engineering capsid-receptor interactions, Ben Deverman, Broad Institute of MIT | ...
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