Epigenome Remodelling in Cancer

A three-dimensional chromatin state underpins the structural and functional basis of the genome by bringing regulatory elements and genes into close spatial proximity to ensure proper, cell-type specific gene expression profiles. We performed Hi-C chromosome conformation capture and replication timing sequencing to investigate how three-dimensional chromatin organization in relation to the epigenome is disrupted in cancer. Our study provides new insights into the relationship between replication timing, long-range epigenetic deregulation and changes in higher-order chromatin interactions in cancer.