Technical Program

Keynote Speaker: Brian Strahl, University of North Carolina at Chapel Hill

Chromatin mechanisms and non-chromatin functions of histone code writers

Session 1: Biophysics of Chromatin

Chaired by Katie Galloway, Massachusetts Institute of Technology

Invited Speaker: Victor Corces, Emory University

Mechanisms of transgenerational transmission of obesity epiphenotypes

Invited Speaker: Anders Hansen, Massachusetts Institute of Technology

Dynamics of 3D genome structure and function

Selected Abstract: Engineering Methylation Pathways for Selective Chemical Tracking of Epigenetic Writers in Mammalian Cells

Saulius Klimašauskas, Vilnius University

Selected Abstract: Suppressing DOT1L Increases Histone Acetylation, Rnapii Elongation, and Nascent Transcription to Enable Pluripotency

Coral Wille, University of Wisconsin Madison

Friday, October 28th

Session 2: Epigenetics in Health & Development

Chaired by Courtney Hodges, Baylor College of Medecine

Invited Speaker: Laura Baranello, Karolinska Institutet

Combined inhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer by inducing readthrough transcription

Invited Speaker: Xiaodong Cheng, MD Anderson Cancer Center

Regulation of Transcription Factor on DNA Binding

Selected Abstract: Epitranscriptomics Marks and Their Governing RNA-Protein Interactions during Environmental Stress

Sean Engels, University of Texas at Austin

Selected Abstract: Dissecting the Therapeutic Window of SWI/SNF Epigenetic Therapy in AML

Courtney Chambers, Baylor College of Medicine

Lunch and Round Tables

Epigenetics in Society facilitated by Luca Chiapperino

Session 3: Perturbing Chromatin and Emerging Technologies

Chaired by Nate Hathaway, University of North Carolina at Chapel Hill

Invited Speaker: Sara Rouhanifard, Northeastern University

Single-Molecule Sequencing and Imaging of Pseudouridine Modifications in the Human Transcriptome

Invited Speaker: Douglas Phanstiel, University of North Caorlina at Chapel Hill

Phase-separation driven chromatin looping in human health and disease

Selected Abstract: High-Throughput Functional Characterization of Combinations of Transcriptional Activating and Repressing Domains

Adi Mukund, Stanford University

Selected Abstract: Using dCas9 to Regulate Endogenous Gene Expression in the Brain

Anne West, Duke University

Keynote Speaker: Marianne Rots, University of Groningen

Awake the sleeping, mute the screaming: towards sustained reprogramming of any given gene by Epigenetic Editing- a historical overview

Session 4: Epigenetic Editing towards the Clinic

Chaired by Elizabeth Heller, The University of Pennsylvania

Invited Speaker: Dan Hart, Epic Bio

GEMS: A platform for transcriptional and epigenetic engineering in human disease

Invited Speaker: Ricardo Ramirez, Chroma Medicine

Development of Epigenetic Editors: A New Class of Genomic Medicines

Invited Speaker: Nicole Palmour, McGill University

Auditing the Editor: Translational Issues in Epigenetic Editing with CRISPR/dCas9

Invited Speaker: Luca Chiapperino, University Lausanne, Switzerland

What place for Responsible Research and Innovation in Epigenetics? Results from the EpiBio Conference Roundtables on 'Epigenetics and Society'

Session 5: Sensing Epigenetic Modifications

Chaired by Karmella Haynes, Emory University

Invited Speaker: Mark Bedford, MD Anderson Cancer Center

The NFIB/CARM1 Partnership in Small Cell Lung Cancer

Invited Speaker: Jennifer Spangle, Emory University

Defining and targeting methylation events in disease

Selected Abstract: Dynamic Reactivation of the G1 Enhancer Landscape Underlies SWI/SNF Addiction

Katerina Cermakova, Baylor College of Medicine

Selected Abstract: Mechanical Regulation of Histone Modifications during TGFβ1-Induced Epithelial-Mesenchymal Transition

Jessica Sacco, The Pennsylvania State University

Session 6: Genomics and Emerging Technologies

Chaired by Kaushik Ragunathan, Brandeis University

Invited Speaker: Oliver Rando, University of Massachusetts Chan Medical School

An updated view of the mammalian sperm epigenome

Selected Abstract: Epigenetic Data Enables the Accurate Prediction of Gene Expression

Alan Cabrera, Rice University

Selected Abstract: An Efficient and Controllable Synthetic Model of Early Embryonic Development Using CRISPR Epigenome Editing

Ali Shariati, University of California, Santa Cruz

Selected Abstract: Utilizing Epigenetic Reader Domains to Demonstrate Nucleosomes, Not Peptides, Dictate the Histone Code

Matthew Meiners, EpiCypher