The purpose of this workshop is to share strategies and tools for commercial bioprocess design and economic analysis. Sef Heijnen will describe, with modest information, how to visualize the outcome – a full scale fermentation process – and the fundamental importance of doing so before a research program is started in order to deliver production microbes that scale successfully. Jeff Lievense and Alex Patist will provide a set of tools for deriving full scale plant capital and production costs given basic information on the product, biochemical stoichiometries, feedstocks, product recovery approach, plant size and location. A quantitative dashboard will be introduced as a means of tracking process development progress and its competitiveness. Three case studies will be presented during the workshop.
8:00-11:00 AM | Workshop- Tools for Commercial Bioprocess Design and Economic Analysis |
8:00-8:05 AM | Introduction- Jeff Lievense, Genomatica |
8:05-8:40 AM | Reverse the Direction in Bioprocess Development: From Full Scale to Synthetic Biology- Sef Heijnen, TU Delft |
8:40-9:40 AM | Economic Analysis of Fermentation Processes (Feedstock, Capital, Production Costs) - Jeff Lievense and Alex Patist, Genomatica |
9:40-9:50 AM | Break |
9:50-10:10 AM | Engineering Cost Model - Alex Patist |
10:10-10:40 AM | Case Studies (3-hydroxypropionic acid, undecanoic acid) - Jeff Lievense and Alex Patist |
10:40-10:55 AM | Process Omics: Chemical Advantage Dashboard - Jeff Lievense |
10:55-11:00 AM | Closing Remarks - Alex Patist |