Re-Assemblying the Peptidoglycan for Enhanced Production of Polyhydroxyalkanoates

Morphology engineering for prokaryote cells involved in many genes related to bacterial shapes. And the manipulation of these genes made the enhancement of polyhydroxyalkanoates production possible. Due to the small size of microorganisms, especially prokaryote cells, it is usually very difficult to separate tiny cells from fermentation media. One of these possible solutions to overcome this obstacle is to manipulate bacterial cell-wall synthesis genes. Once the speed of bacterial cell-wall synthesis is consistent with the accumulation speed of polyhydroxyalkanoates granules, much more bigger cells can be obtained and separated from fermentation media. It is therefore desirable to find an alternative economic way to achieve the separation.