Improvement of DNA synthesis

M. Horlacher, P. Kuhn, K. Heil, K. Wagner, C. Bauer, T. Poehmerer, M. Liss, A. Trefzer

In the few last years the price for DNA synthesis has decreased rapidly, opening up new markets for commercial gene synthesis suppliers. However, the current technology is reaching a limit with respect to cost reduction, constrained by synthesis scale and error rate.
In our efforts to keep offering our customers top quality synthetic DNA products, we continuously improve our oligonucleotide and gene synthesis workflows. We further develop parts of the process regarding cost reduction, time reduction, higher stability and higher efficiency. This allows us to target the market demand of lower costs for synthetic genes.
We will show data illustrating our efforts to reduce error rate both by improved oligo synthesis as well as error correction of assembled genes. In combination these developments continue to drive overall improvements in DNA synthesis.