Nanoparticle Therapeutics for Treating Cancer and Other Diseases of the Brain

We have translated three nanoparticles into the clinic for use as cancer therapeutics. One of these nanoparticle, experimental therapeutics was the first to show functional RNA interference (RNAi) in humans. At this time, these nanoparticles have been investigated in over 10 different clinical trials. I will describe how we translated these nanoparticles from the laboratory at Caltech into clinical, experimental therapeutics. In addition to investigations of nanoparticle-based therapeutics for cancer, we are now concentrating on developing nanoparticles that cross the blood-brain-barrier for treating cancer and other diseases in the brain. Our recent efforts will be presented.