(162b) Jujube Enhances Anti-PD-L1 Efficiency Against Murine Colon Canser through Modulating Andfueling Gut Microbiota

Ziziphus jujube, also known as Chinese date, are extensively used as an adjuvant in traditional Chinese medicine, including digestion enhancement and the treatment of loose stools in deficiency syndromes of the spleen. Of our particular interest is that jujube contains a large amount of carbohydrates and can be fermented in the intestine to produce short-chain fatty acids (SCFAs), thus improving the gastrointestinal milieu. We thus came to the idea of supplying jujubes to patients receiving ICIs treatment in order to enrich the probiotics in the intestines and, eventually, improve the efficiency of ICIs. In this work, we demonstrated this idea using mouse MC38 colon tumor model. We observed that the administration of jujube powder has improved both the response rate and therapeutic efficiency of anti-PD-L1. The increased the species richness of Lachnospiraceae while decreased the abundance of Prevotellaceae was also observed from those positive cases where enhanced immune cell responses appears, especially CD4+ and CTL cells. These findings are significant to understand the mechanism of jujube as immune adjuvants and display the healthy and medical function of jujube.