(506d) Optimizing Continuous Powder Mixing Processes Using Periodic Section Modeling
AIChE Annual Meeting
2011
2011 Annual Meeting
Food, Pharmaceutical & Bioengineering Division
Applications of Continuous Processing In Manufacture of Drug Product
Wednesday, October 19, 2011 - 1:45pm to 2:10pm
Optimizing
continuous powder mixing processes using periodic section modeling
Yijie Gao, Fernando Muzzio and
Marianthi G. Ierapetritou
Dept. of Chemical and Biochemical Engineering, Rutgers
University, Piscataway, NJ 08854
Continuous
powder mixing is considered as an advantageous choice to batch mixing for
better controllability and easier scale-up of production rate. Many works have
been performed on the performance improvement of the continuous mixing process.
In this study, the effects of operating conditions are investigated. Using the
periodic section modeling developed in our previous study 1,
we investigated the effects on cross-sectional mixing, and on axial mixing and motion.
The variance decay rate of the batch-like mixing in the cross-sectional
directions (kb), as well
as the mean particle velocity in the axial direction (vx), is used as key
indices of performance in the continuous mixing process.
We consider mixing
at different fill levels and blade speeds in order to characterize their
effects on powder mixing. Mixing cases with materials of different particle
size, particle density and cohesiveness are also compared. Results show similar
contours for both kb and vx
among the studied cases, indicating that the optimal operation obtained in
continuous mixing of one mixing case can be directly used as the optimal
condition at another case. Based on the characteristics of contours, it is also
noticeable that both variance decay rate kb
and axial velocity vx
increase with the blade speed. This leads to a trade-off on the improvement of
the overall cross-sectional mixing efficiency. To resolve this issue, two
operating parameters are changed simultaneously, i.e. increase of blade speed
and decrease of blade angle, or increase of both blade speed and weir height.
While variance decay rate kb
increases proportionally with blade speed, an approximately constant axial
velocity vx
is obtained using this strategy. Results show dramatic improvement of the
overall cross-sectional mixing efficiency, and provide a promising direction
towards optimizing continuous powder mixing design and operating conditions.
Reference