(560db) Electrostatically Enhanced Catalytic Phase Transfer Hydrogenation of Acetophenone Under Low External Electric Field
AIChE Annual Meeting
2019
2019 AIChE Annual Meeting
Catalysis and Reaction Engineering Division
Poster Session: Catalysis and Reaction Engineering (CRE) Division
Wednesday, November 13, 2019 - 3:30pm to 5:00pm
In the present work, the OEEF promoted phase transfer catalysis reaction was reported for the first time. The reaction of choice for this study was the transfer hydrogenation of acetophenone, with sodium formate as the hydrogen source. The two phase system was established with acetophenone/organic solvent as the less dense organic phase and sodium formate solution as the more dense aqueous phase. An external electric field was applied across the two phases without any agitation. It was demonstrated experimentally that an OEEF can act as promoter or inhibitor for the phase transfer hydrogenation of acetophenone depending on its direction, showing a potential on controlling rate of chemical reactions. With 1-butanol as organic solvent, the conversion can be achieved as high as 86% with an enantioselectivity of 94% under room temperature and pressure. This work presents a methodology for promoting PTC reactions in the absence of a chemical phase transfer agent and shows promise for significantly improving the performance of organic reactions with OEEF in biphasic liquid systems.