(640b) Vision-Guided, High-Throughput Liquid-Liquid Extraction Screening

In a small molecule manufacturing process, optimization of workup parameters is critical for reducing plant operational costs, cycle time, and process mass intensity (PMI). However, identifying appropriate conditions for workup procedures, such as liquid-liquid extractions (LLE), can often be both time and operationally intensive. To address these challenges, we have developed a novel automated platform to enable rapid optimization of LLE conditions. This presentation will highlight a data-rich approach to screening workup conditions by leveraging high-throughput experimentation and automation. Direct application of this platform in recent pipeline projects will also be discussed. Notably, application of this automation platform has enabled access to workup conditions that provide access to greener solvent conditions, reduced PMI, and enhanced robustness across the overall process.