(15d) Mechanochemical Preparation of Nano-Sized Pharmaceutical Drugs for Application in Cancer Therapy
AIChE Spring Meeting and Global Congress on Process Safety
2006
2006 Spring Meeting & 2nd Global Congress on Process Safety
Fifth World Congress on Particle Technology
Structure-Property Relations in Particle Formation Processes - I
Monday, April 24, 2006 - 9:00am to 9:20am
The mechanochemical transformation of ?Ñalfa-realgar As4S4 to its high temperature polymorph ?"beta- form has been studied. The size dependance of this transformation was elucidated for particle size 25-62 nm. The mechanochemical transformation is hindered by agglomeration effects in this case. The identified phenomena - polymorphous transformation, new surface area formation and preparation of realgar particles in nanosize - are expected to have good impact on solubility as well as bioavailability of realgar as a potential new pharmaceutical drug for leukemia treatment.
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