Sharvari Kemkar

I am a fourth-year PhD student in the Chemical and Biomolecular Engineering Department at the University of Pennsylvania, additionally pursuing a master's in Scientific Computing. Previously, I graduated with a bachelor's (with honors) in Chemical Engineering and a minor in Bioengineering from IIT Bombay (India) in 2021. I build multiscale spatiotemporal models for precision medicine, specifically heterogeneous solid tumors. Utilizing patient-specific multi-omics, I tune physics-based cellular behaviors and other stochastic interactions in a multi-agent simulation to observe the resultant patient-specific collective tissue dynamics. We then employ machine learning to build surrogates for these models, enhancing computational efficiency, enabling extensive global sensitivity analysis, and exploring verification, validation, and uncertainty quantification methods. This protocol can facilitate the development of verifiable cancer digital twins, enabling the prediction of patient-specific responses to clinical therapies and advancing precision medicine in oncology.