Comparison of a microtiter plate‐based cloning workflow vs. a nanofluidic chip subcloning workflow. A depiction of the steps involved in performing a clonal isolation and expansion workflow using two approaches. Differences are highlighted in boxes for FACS‐based workflow (solid) and Beacon workflow (dotted).
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A recently published Biotechnology Progress article, “A Novel Mammalian Cell Line Development Platform Utilizing Nanofluidics and OptoElectro Positioning Technology” by Kim Le (corresponding author) and Christopher Tan of Drug Substance Technologies, Process Development, Amgen Inc., Thousand Oaks, CA, and several other authors affiliated with Amgen, is receiving tremendous attention from news media and social media.
A nanofluidic-based method for obtaining clonal cell lines is described. When compared head to head with a FACS‐enabled microtiter plate‐based workflow, the generation of clonal cell lines with comparable productivity or increased “specific productivity,” but with reduced resources and increased information about each clone are the reported outcomes.
Altmetric Attention Score
The article has an outstanding Altmetric Attention Score of 107.
This Attention Score is in the top 5% of all research outputs scored by Altmetric. The article has been mentioned by 14 news outlets and Twitter.
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Biotechnology Progress
Biotechnology Progress, the official publication of AIChE’s Society for Biological Engineering, delivers peer-reviewed research reports and reviews in the fast-evolving bioprocessing, biomedical, and biomolecular fields.
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