New Technologies from Engineered Chimeric Proteins | AIChE

New Technologies from Engineered Chimeric Proteins

We engineer designer fusion proteins that combine domains and functions from unrelated proteins and enzymes. In bioseparations, we have combined a previously developed pH-sensitive self-cleaving protein with a variety of purification tags to produce simple and economical methods for purifying recombinant proteins. In biosensing, we have developed allosteric proteins that cause Escherichia coli strains to become growth-dependent on endocrine active compounds. Remarkably, this genetically simple bacterial sensor can differentiate agonist from antagonist activities and has been effective in detecting estrogenicity in a wide variety of pollutants, home products and natural herbal remedies.


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  • Source:
    SBE - Society for Biological Engineering
  • Language:
    English
  • Skill Level:
    Advanced
  • Duration:
    1 hour
  • PDHs:
    1.00